If you really want and desire the Byzantine empire to survive longer, how about making sure that Justianian ignores taking back the land which belonged under the Roman Empire, and focuses on making sure the plague does not ravage through Byzantine land, and that Persia does not invade Byzantine provinces. You have a nice pod, of course, but you see, the Fourth Crusade was mainly called on Byzantium because of differences between the Greek Orthodox and the Roman Catholic branches of Christianity, and because of Venetian greed.
In reality it could also be fine, a Roman Empire post the Justinian reconquests, especially if Justin II and Tiberius II manage to obtain an earlier peace with Persia compared to Otl, allowing Maurice to have much better state finances and perhaps with Chosroes II still indebted to him, to concentrate again on the western front ( Italy and the Balkans first and foremost, with the fights against the Moors immediately following ) with the right calm, even if I would just make a small change, that is, immediately form an alliance with the kings Merovingians, in function anti-Lombard, Visigoth and Avar ( since they are common enemies of both Rome and the Franks ) but also the mere fact of making the Gothic wars less devastating and expensive, decreeing a single commander in office instead of the chaos of Otl, not separating Sicily and Sardinia from the Italian province as has historically happened ( a terrible choice, which weakened the Roman position in the region especially after the arrival of the Lombards ) it should allow the Empire to be in a better situation than in Otl
certainly avoiding the 4th crusade would be a possible solution, but it would not solve the problems that grip Byzantium : the internal ones which are the deep internal divisions, with pushes for independence ( as in Cyprus, Trebizond and Bulgaria, all crises occurred well before the fateful 1204 ) the economic weakness resulting from the competition of Italian traders ( who are clearly superior to their Rhomanois counterparts ) is finally the deep hatred that is forming between the Latins and Byzantium, after a century of hostile cross-propaganda, profound xenophobia on the part of the aristocracy and clergy of Constantinople, and hostile acts on both sides parts ( the massacre of the Latins of 1182 and the numerous Norman-Roman wars and the skirmishes during the various crusades ) therefore it would be quite complicated to resolve or mitigate these problems, even with a Pod that allows Manuel I to live a few more years, so to allow Alexios II to come of age and then succeed his father
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